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ORIGINAL ARTICLE
Year : 2015  |  Volume : 32  |  Issue : 1  |  Page : 41-48

Protective effect of Nigella sativa against cerebral ischemia and sodium valproate-induced hepatotoxicity


Department of Pharmacology and Therapeutics, Faculty of Medicine, Benha University, Benha, Egypt

Correspondence Address:
Yasmin M Ismail
Department of Pharmacology, Faculty of Medicine, Benha University, 3112 Benha
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.170558

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Background Nigella Sativa (NS) is one of the traditionally used herb well known for its healing properties. The most of the therapeutic properties of this plant is due to the presence of Thymoquinone (TQ), the major bioactive component of the essential oil. TQ is also a promising dietary chemopreventive agent for the treatment of number of diseases. Very low level of toxicity has been reported through acute and chronic toxicity studies. Aim The present study aimed to investigate the anti-ischemic effect of NS using carotid artery occlusion model in rats.This study also aimed to investigate the effect of NS on SVP induced hepatotoxicity. Method 0Animals given NS and TMZ for 21 days then subjected to 45 min for brain ischemia then reperfusion.Animals administered NS, SVP for 21 days then subjected to serum measurement of serum ALT & AST and liver histopathological examination. Results NS significantly reduced the percent of necrosis and reduced the size of cerebral infarction compared to control and enhanced the effect of TMZ on cerebral ischemia.NS produced significant decrease in serum ALT and AST and improvement of histopathlogical picture compared to SVP group. Conclusion These results indicate that the NS could have a therapeutic effect against cerebral ischemia.NS has protective effect against SVP induced hepatotoxicity.


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