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ORIGINAL ARTICLE
Year : 2016  |  Volume : 33  |  Issue : 2  |  Page : 65-71

Genetic variations in the growth arrest-specific 6 protein gene in patients with acute coronary syndrome


Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha, Egypt

Correspondence Address:
Mohamed M Elshafey
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha 13111
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.201290

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Growth arrest-specific gene 6 (GAS6) encodes a vitamin K-dependent protein that regulates inflammation, angiogenesis, and atherosclerotic plaque formation. The level of GAS6 expression is associated with plaque stability and stroke. The role of GAS6 in cardiovascular disease, particularly in acute coronary syndrome (ACS), was explored. The study investigated the role of the single nucleotide polymorphism (c.834 + 7G >A) of GAS6 in ACS. The genotype frequencies for GG, AG, and AA, respectively, in patients with ACS were 57.1% (16/28), 28.6% (8/28), and 14.3% (4/28) and were 20% (4/20), 40% (8/20), and 40% (8/20) in the control group. The AA genotype and A allele were less frequent in patients with ACS than in controls (P < 0.05). Our study indicates that the AA genotype and A allele of the GAS6 gene relate to ACS and may have a protective role against ACS.


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