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ORIGINAL ARTICLE
Year : 2017  |  Volume : 34  |  Issue : 1  |  Page : 5-9

Tumor necrosis factor-α promoter gene polymorphism (308 G/A) in the Egyptian patients with systemic lupus erythematosus


1 Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt
3 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Benha University, Benha, Egypt

Correspondence Address:
Walid A Abdel Halim
Department Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha 13512
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.206895

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Background Tumor necrosis factor-α (TNF-α) is a very important cytokine having different physiological and pathogenic effects that lead to tissue destruction. The polymorphism of the TNF-α promoter gene at position –308 has been thought as a genetic risk factor for systemic lupus erythematosus (SLE). Thus, we aimed in this study to evaluate the association between TNF-α gene polymorphism (308 G/A) and SLE in the Egyptian population and its relation to the activity and the clinical manifestations of SLE. Participants and methods A case–control study was performed on 50 female patients with SLE (mean age, 32.4 ± 8.6 years) and 50 female healthy volunteers (mean age, 31.9 ± 8.3 years) served as controls. Genotyping was carried out by PCR. The PCR products were digested by NcoI restriction enzyme. Results TNF-α promoter gene polymorphism (rs1800629) GA and AA genotypes and A allele were significantly increased in the studied SLE patients when compared with healthy controls (P = 0.023 and 0.007, respectively). TNF-α genotypes showed significant differences between the various Systemic Lupus Erythematosus Disease Activity Index activity grades (P = 0.012). Moreover, GG genotype had a significantly lower incidence of renal disorders and persistent proteinuria when compared with AG or AA genotypes (P = 0.006 and 0.001, respectively). However, AA genotype showed a significantly higher incidence of neurologic disorders when compared with GG and AG genotypes (P < 0.001 and P = 0.026, respectively). Conclusion Our results indicate that TNF-α (–308 G/A) polymorphism may have a role in the susceptibility and pathogenesis of SLE in the Egyptian population.


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