• Users Online: 161
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 34  |  Issue : 2  |  Page : 146-151

CD4+ CD28null in cases of polycystic ovary syndrome


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Obstetrics and Gynecology, Egyptian Ministry of Health and Populations, Sherbin General Hospital, Egypt

Correspondence Address:
Afaf R.A Al-Said
Thawra Street, Kafr Saad, Damietta, 34517
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_70_17

Rights and Permissions

Background The immunopathogenesis of polycystic ovary syndrome (PCOS) is established. However, the role of CD4+ CD28null in such patients is underinvestigated. Aim The aim of this study was to evaluate and compare CD4+ CD28null T cells in patients with polycystic ovary (PCO) (with high androgen level and with normal androgen level) and non-PCO patients. Patients and methods This study was carried out at Benha University Hospital. It included 100 PCO patients and 50 controls selected from the gynecology and obstetrics outpatient clinics. All included female patients were subjected to history taking and clinical examination. Transvaginal ultrasound was performed to confirm the ultrasonic criteria of PCOS. Hormonal profile included the evaluation of thyroid-stimulating hormone, prolactin, dehydroepiandrostendione-S total testosterone, lipid profile, and fasting blood glucose. Finally, total lymphocytic count, CD4 T cell, and CD4+ CD28null frequency were evaluated. Results Ovarian volume was significantly increased in higher and normal androgen subgroups (11.18±1.31 and 10.53±0.84) when compared with the control group (7.15±1.66). Immunological profile revealed that there was a significant increase in total lymphocyte count and CD4+ CD28null in the study group when compared with the control group. In addition, there was a significant increase in total lymphocyte count and CD4+ CD28null in both higher and lower androgen subgroups when compared with the control group. Finally, there was a significant increase in CD4+ CD28null in higher androgen when compared with lower androgen subgroup (3.15 vs. 2.73, respectively). Conclusion There was a higher expression of CD4+ CD28null T cells in PCOS, especially with hyperandrogenic state.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed128    
    Printed0    
    Emailed0    
    PDF Downloaded32    
    Comments [Add]    

Recommend this journal