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ORIGINAL ARTICLE
Year : 2017  |  Volume : 34  |  Issue : 2  |  Page : 98-103

Prevalence of sensitization to mould and yeast allergens in Egyptian patients with respiratory allergy


1 Department of Internal Medicine, Benha Faculty of Medicine, Benha University Hospitals, Benha, Egypt
2 Department of Internal Medicine, Allergy and Clinical Immunology Unit, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt

Correspondence Address:
Medhat M Elamawy
Department of Internal Medicine, Faculty of Medicine, Benha University Hospitals, Benha, 13518
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_149_17

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Background Burden of fungal allergic diseases to humans is broad and still needs much clarification on the prevalence of its related disease. Asthma-related deaths, hospital admissions, respiratory symptoms, and pulmonary functions can be adversely affected by high fungal spore concentrations in outdoor air. Aim The aim of this study was to evaluate the prevalence of sensitization to various species of mould and yeast allergens among other common aeroallergens in Egyptian patients with respiratory allergy diseases. Patients and methods Totally, 200 patients with allergic bronchial asthma and/or allergic rhinitis were selected from those followed up at the Allergy and Clinical Immunology Clinic at Ain Shams University Hospitals. For each patient, detailed allergic history and clinical examination were carried out. Asthma control level and severity of allergic rhinitis were classified according to 2015 Global Initiative of Asthma report and Allergic Rhinitis and its Impact on Asthma 2008, respectively. Complete blood count and Spirometry were done. In addition, skin prick test to 10 mould allergens, besides other six common aeroallergens and positive and negative controls, were carried out. Statistical package for the social sciences was used. Results The results revealed that 74% had positive results to at least one allergen extract. Out of skin prick test-positive participants, 41.9% showed positivity toward fungal allergen. Alternaria alternate and Penicillium spp. mixture each represented 32.2% of positive fungal sensitivity patients. Moreover, 38.9% of poorly controlled asthmatic patient’s category was fungal sensitized, whereas the percentage in well-controlled patients was 30.8% and it was a significant finding as P value was 0.02. Conclusion Fungal sensitivity is clearly correlated with respiratory allergic disease and its severity.


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