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CLINICAL TRIAL
Year : 2018  |  Volume : 35  |  Issue : 1  |  Page : 20-23

Nebulized fentanyl: is it effective in pediatric postoperative analgesia?


Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, Mansoura, Egypt

Correspondence Address:
Hani I Taman
Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, 10 Gehan Street, Mansoura, 35511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.226408

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Background Postoperative pain management in pediatric patients is challenging. Intravenous (IV) fentanyl appears to be an appropriate solution; however, nebulized fentanyl could be a new, promising, noninvasive method for systemic fentanyl administration with less side effects in pediatric patients. Patients and methods A total of 40 pediatric patients who underwent lower abdominal surgery under general anesthesia were classified into two groups − group IV received 1 µg/kg IV fentanyl and group N received 2 µg/kg nebulized fentanyl. Observations were made with regard to pain relief by the FLACC score and sedation by the Ramsay score. Hemodynamics and other side-effects such as vomiting, bradychardia, hypotension, and pruritus were also recorded. Results Although FLACC changes were observed in lesser than 10 min after initiation of drug administration in group IV when compared with group N, incidence of side-effects in group IV was higher when compared with group N. The rapidity of onset of fentanyl’s analgesic effect was faster in group IV followed by group N. No differences were found between the two groups with regard to the Ramsay score. Conclusion We found that 2 µg/kg nebulized fentanyl has equal analgesic effects with less side-effects compared with 1 µg/kg IV fentanyl but with slower onset of action.


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