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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 1  |  Page : 28-35

Role of vascular adhesion protein-1 in patients with alopecia areata


1 Department of Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
3 Department of Venereology and Andrology, Kafr Shokr Central Hospital, Benha, Egypt

Correspondence Address:
Fatma Y Abd El-Aziz Anwer
Abd-Elrahman Gab Allah Street, New Benha, Benha City, Qalyubia Governorate, 13511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.226420

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Objective The aim of this study was to detect the role of vascular adhesion protein-1 (VAP-1) in patients with alopecia areata (AA). Background AA affects about 2–3% of new patients attending dermatology clinics. The etiology of AA is still largely unknown. Clinically, AA presents as an area of well-circumscribed patch of sudden hair loss. The severity of disease is graded using Severity of Alopecia Tool score. Treatment depends on disease involvement. In 1996, Arvilommi and colleagues reported that about 75–100% of dermal vessels in skin lesions demonstrated positive VAP-1 expression. Patients and methods This study included 50 patients with AA (group A), and 30 apparently healthy individuals of matched age and sex were chosen as a control group (group B). All patients were selected from the Outpatient Clinic of Dermatology and Andrology Department of Benha University Hospitals. Results The mean±SD age of the patients was 27.3±14.05, whereas the mean±SD age of the control group was 32.8±11.27 years. Serum level of VAP-1 was higher in AA patients with progressive course compared with patients with constant course. Serum VAP-1 level was variable according to the pattern of hair loss in the patient group. The VAP-1 level according to the presence or absence of exclamation mark was not statistically significant. There was a highly significant variation in serum VAP-1 level according to psychological stress. VAP-1 level was not statistically significant according to the presence or absence of nail pitting. There was a highly statistically significant correlation between VAP-1 level and the Severity of Alopecia Tool score. There was a statistically significant correlation between VAP-1 level and the number of lesions. There was no statistically significant correlation between VAP-1 level and the size of the lesion. There was no statistically significant correlation between VAP-1 level and the age of the patients and the duration of the disease. Conclusion Serum VAP-1 level is an important marker for the early diagnosis (prediction) of suspicious cases of AA, prognosis of the disease, the course of the disease, and whether the case will progress to alopecia totalis or universalis or it will remain stationary. It can be a target for new therapeutic lines for the disease.


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