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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 1  |  Page : 36-41

Serum level of Golgi protein-73 as a diagnostic marker for hepatocellular carcinoma


1 Department of Internal Medicine, Faculty of Medicine, Benha University, Banha, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Benha University, Banha, Egypt

Correspondence Address:
Raafat S Salem
Benha Faculty of Medicine, Benha, 13511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_173_17

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Background Golgi protein-73 (GP73) as a potential serum marker for hepatocellular carcinoma (HCC) has not been validated in studies. The aim of this study was to determine the value of serum Golgi protein-73 (SGP73) in the diagnosis of HCC. Patients and methods SGP73 and α-fetoprotein (AFP) were compared in a total of 80 human participants in this study; 35 patients with HCC, 35 patients with cirrhosis, and 10 healthy controls were included. Results Using 10.3 relative units as a cut-off value, the sensitivity and specificity of SGP73 for HCC were 97.1 and 85.7% compared with 57 and 55.6% for AFP (P<0.001) using 100 ng/ml as a cut-off value. The GP73 level was significantly increased in patients with HCC compared with the healthy controls (35.55 vs. 4.13%, P<0.001). Conclusion GP73 is an accurate serum marker for the detection of HCC with higher sensitivity and specificity than AFP.


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