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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 1  |  Page : 67-73

The potential effect of vitamin D on rats with fatty liver induced by a choline-deficient diet


Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt

Correspondence Address:
Dania A Mohammed
Department of Physiology, Faculty of Medicine, Benha University, Benha, 13511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_3_17

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Background Nonalcoholic fatty liver disease (NAFLD) is present worldwide and is considered the most common cause for abnormal liver function tests and chronic liver disease in both developed and developing countries. Aim This study aimed to investigate the effect of pretreatment with vitamin D on NAFLD and the role of transforming growth factor-β1 (TGF-β1) in vitamin D-mediated hepatoprotective effect. Materials and methods NAFLD was induced in albino rats by administration of a choline-deficient diet. Serum activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), serum levels of albumin, bilirubin, and 25 hydroxyvitamin D [25(OH)D], body weight, liver weight, and liver index were measured in different experimental groups to assess liver affection. In addition, TGFβ1 was immunohistochemically determined. Results NAFLD caused significant increases (P<0.005) in serum levels of AST and ALT, liver weight, and liver index, with a significant decrease (P<0.005) in serum levels of 25(OH)D. Administration of vitamin D (1, 5, and 10 μg/kg) caused a significant reduction (P<0.005) in serum levels of AST and ALT, liver weight, and liver index with a significant increase (P<0.005) in serum levels of 25(OH)D. TGFβ1 expression showed improvement in a dose-dependent manner. Conclusion Vitamin D has a hepatoprotective effect in NAFLD induced by a choline-deficient diet, and TGFβ1 contributes to this protection.


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