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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 1  |  Page : 89-96

Erythropoietin versus allopurinol on ischemia/reperfusion-induced acute kidney injury in rats


1 Clinical Pharmacology Department, Faculty of Medicine, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt
2 Pathology Department, Faculty of Medicine, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt
3 Veterinarian Team, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt
4 Clinical Pathology Department, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt
5 Department of Public Health, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt
6 Urology and Nephrology Center, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Rehab H Ashour
Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, 35511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_165_17

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Objective Renal ischemia/reperfusion (I/R) injury involves multiple mechanisms including oxidative stress. Erythropoietin (EPO) and allopurinol have an antioxidant effect and are protective against I/R-induced kidney injury. This study compares the ability of EPO to compete oxidative stress and kidney injury induced by I/R with that of allopurinol. Materials and methods A total of 72 male Sprague–Dawley rats were randomized into the following groups: sham group, I/R group, EPO-treated I/R group, and allopurinol-treated I/R group (n=18 in each group). I/R was persuaded by 45 min clamping of the left renal pedicle followed by right nephrectomy. The therapeutic intervention started before the operative procedure. In each group, animals were killed at 1, 3, and 7 days after the operation. Serum creatinine, serum aspartate aminotransferase, tissue malondialdehyde, and pathological score for injury and regeneration were determined. Results We found that both EPO and allopurinol were able to attenuate the elevation of serum creatinine. EPO was more effective than allopurinol in reducing aspartate aminotransferase and malondialdehyde levels. Both drugs were equally effective regarding their effect on the active injury and regeneration scores. Conclusion These results indicate that although EPO or allopurinol can effectively reduce kidney damage, EPO is a better choice as an antioxidant and for reducing the overall damage of I/R-induced kidney injury.


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