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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 2  |  Page : 139-144

Vaginal fluid prolactin in cases of suspected premature rupture of fetal membranes


Department of Obstetric and Gynacology, Shebin El-Kom Teaching Hospital, Menoufia, Egypt

Correspondence Address:
Dr. Mahmoud E.A. Donia
Department of Obstetric and Gynacology, Shebin El-Kom Teaching Hospital, Menoufia, 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_157_17

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Objectives The aim of this study was to evaluate vaginal fluid prolactin (PRL) as a diagnostic tool in cases of suspected premature rupture of fetal membranes and to get a cutoff value of PRL level for the definitive/diagnosis of premature rupture of membranes (PROM). Backgrounds Preterm PROM refers to a patient who is before 37 weeks’ gestation and has presented with rupture of membranes (ROM) before the onset of labor. Spontaneous PROM is ROM after or with the onset of labor. Prolonged PROM is any ROM that persists for more than 24 h and before the onset of labor. Patients and methods This case–control study was performed on 150 pregnant women attending casualties and outpatient clinics at Shebin El-Kom Teaching Hospital. The study included three groups: group 1 included 50 women with suspected PROM; group 2 included 50 women with definitive PROM; and group 3 included 50 healthy pregnant women as a control group. All study participants were subjected to full history, examination, ultrasonography, collection of 3 ml of vaginal fluid, and measurement of PRL concentration. Results There were high statistically significant differences between women of the three groups concerning amniotic fluid index and cervicovaginal PRL concentration (P=0.001). Receiver operating characteristic curve was constructed for vaginal PRL concentration as a predictor of PROM. Vaginal PRL concentration is a good predictor of PROM (P=0.001). Conclusion Vaginal fluid PRL can be used in suspected cases of ROM; the cutoff value was 4.38 ng/ml and vaginal fluid PRL is a simple, cheap, rapid, and reliable test.


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