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ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 2  |  Page : 257-263

Relationship between serum sialic acid concentration and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus


1 Endocrinology Unit, Internal Medicine Department, Faculty of Medicine, Benha University, Banha, Egypt
2 Internal Medicine, Faculty of Medicine, Benha, University, Banha, Egypt
3 Hepatology and Tropical Medicine Research Institute, Cairo, Egypt

Correspondence Address:
Dr. Ahmed E Mansour
Internal Medicine, Faculty of Medicine, Benha, University, Banha, 13511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bmfj.bmfj_17_18

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Background Degree of diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus (DM) and one of the most common causes of blindness worldwide. Plasma sialic acid (SA) is one of the markers that has been utilized as an acute-phase response. In DR, there is a great increase in SA. Aim We aimed in this study to shed light on the relationship between serum SA and DR in Egyptian patients with type 2 DM. Patients and methods The patients of this study included 40 patients with type 2 DM (25 with DR and 15 without DR) as well as 10 healthy volunteers as control. A questionnaire was done to every patient including baseline characteristics, examination, laboratory investigations, and dilated fundus examination. Results Serum SA level was found to be significantly increased in patients with type 2 DM compared with control and in diabetic patients with retinopathy compared with diabetic patients without retinopathy. Conclusion This study showed that DR has a significant impact on serum SA level.


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