• Users Online: 1069
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 35  |  Issue : 3  |  Page : 378-385

Protective effect of captopril on cardiac fibrosis in diabetic albino rats: a histological and immunohistochemical study

1 Department of Anatomy, Faculty of Medicine, Al-Azhar University, Damietta, Egypt
2 Department of Anatomy, College of Medicine, Mansoura, Egypt

Correspondence Address:
Dr. Hamdino M Attia
Department of Anatomy, Faculty of Medicine, Al-Azhar University, Damietta (34518)
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bmfj.bmfj_122_18

Rights and Permissions

Background Cardiomyopathy is one of the common complications of diabetes mellitus. Aim The aim of the present study was to investigate the effects of Captopril on myocardial fibrosis in streptozotocin-induced diabetic rats (an animal model of type 1 diabetes mellitus). Materials and methods Forty albino rats were divided into five groups. Group I (control group), group II (untreated diabetic rats), group III (insulin-treated diabetic rats), group IV (Captopril-treated diabetic rats), and group V (insulin and Captopril-treated diabetic rats) were killed at 4 and 8 weeks, and the samples were collected for histological evaluation using hematoxylin and eosin, Masson trichrome, and immunohistochemical staining with anti-P53 for apoptosis, alpha smooth muscle actin (α-SMA) for collagen deposition. Results Treatment of streptozotocin-induced diabetic rats with insulin and Captopril (group V) showed marked decrease in myocardial injury and apoptosis, which was confirmed by marked decrease of sarcoplasmic p53 expression. Group V also showed decreased collagen deposition as confirmed by Masson trichrome staining and α-SMA expression. The results were better after 8 weeks compared with those after 4 weeks. Conclusion The administration of Captopril alone with diabetic rats minimally affected cardiac fibrosis, while the combination of Captopril and insulin markedly improved cardiac fibrosis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded255    
    Comments [Add]    
    Cited by others 3    

Recommend this journal